The camshaft was a big improvement on my truck. The 600 motors use a very retarded (no pun intended) cam design. I have also seen some 555 motors that did not see near as much increase with the same cam change I did.
Good side
Increased fuel milage in the upper RPM band. ( it used to be if I cruised above 65 MPH my fuel milage dropped off fast from 19. 5 down to 17. 5 MPG. Now I can cruise at 75 MPH and still get around 20 MPG)
Broader TQ band. Power comes on quicker and holds on longer
Faster spool up.
Truck burns cleaner and cooler. Between the cam, Smarty and Don M injectors, my EGT's seldom ever cross 1150 degrees. And that is running on level #9
Bad Side
Initial cost to do it.
Labor cost if you do not do it yourself.
other than that, I can think of no other reason why I would not do one. It was one of my best mods.