Originally posted by RustyJC
Running one offset wheel (either the inner or the outer) by itself will move the point at which the load is being applied through the tire(s) inboard or outboard by 1/2 the distance between the centerlines of the treads of the dually tires. In a dually setup, the effective point of load application is midway between the two tires. When only one tire is installed, the point of load application is at the certerline of the tread of that tire. The net effect is to move the load either inward or outward on the hub bearings of the rear axle. This can cause shortened bearing life or bearing failure - think of it as being similar to a severely reversed wheel causing failure of front wheel bearings on a car.
Rusty