TowPro,
Where you guys are getting confused is by considering the mounting point of the rim into the issue. The force is exerted by the weight of the truck (GAW - rear) pushing upwards on the axle. That force is given leverage by the distance from the center of the wheel to the center of the wheel bearing. On a dually the "center of the wheel" is actually the mounting flange. With the inner wheel missing, you have moved the leverage point by approximately 5 1/4" (farther out). As Rusty pointed out, the mounting flange position is irrelevant (unless you want to start calculating the force on the wheel studs and lug nuts). The wheel is bolted to the hub and becomes one single part as far as calculating force on the wheel bearings is concerned.
Before anyone gets excited, No the truck isn't going to fall to the ground in the 1st mile you run it with only one wheel, but all things being equal (GAW - rear) the bearings WILL wear faster than with both wheels. How much faster, I don't know, but I won't be running my truck around all winter with only two wheels on the back. If I was going to run with only one wheel, I'd use a SRW rim with the proper offset. If you're going to be lightly loaded or empty, you'd likely not live long enough to see the wheel bearings actually fail.
Cheers,
Dave