dspoon,
Since we don't know what your setup is or year model, it is hard to relay pertinent information.
However, I will tell you what I have done on my '99. My truck is a 5 spd. My first 5th wheel trailer weighed 8800#'s loaded, so gross combined was 16,400#'s. I bought the Edge EZ for my at that time stock truck. That gave me just enough HP to handle most situations and it kept my EGT's below 1200deg. even when pulling hard, since the EZ comes with a boost elbow. In 2004, we bought our current 5th wheel, and GCW went to 20K+. I chose 350RWHP for towing as a goal, and bought an entire array of performance parts, not including the Edge Comp, to get there. See my sig for reference.
The EZ failed, so I purchased an Edge Comp to replace. I have not been able to tow with the Comp on any setting, due to a miss that starts under load. I can turn the comp on level 1x1, and get much better economy (11mpg vs 9mpg w/o Comp) as long as I am on flat ground or downhill. I turn the comp off as soon as I start up a hill or to pass.
Edge has replaced the comp 4 times under warranty, and the problem is still there. I suspect that the timing is the issue, and any box that adds timing would likely do the same thing on my truck. I can disconnect the pump wire, and the problem almost goes away, occuring only under certain conditions.
I know a lot of other TDR members are using the comp with no trouble. But there are also members having the same issue I am. Do some searches, and you will find a lot of threads.
Since I have not been able to solve my problem, I can't tell you what setup will work with the comp. I can tell you that towing with the EZ, I toasted my stock clutch on level 3, and that was with the otherwise stock truck. I went with a SouthBend MU13 Con OFE, and I can highly recommend them.
Edge is good to work with, at least until they can't solve an issue. They found nothing wrong with the units I returned, except for one. I have no trouble with the unit I have, without a heavy load under acceleration.
Hope this helps,
Jeff