Compression is part of the equation in making big diesel power. The CR Cummins in over 17 to 1 stock. If you are going to effectively rise to intake track pressure to something around 60 lbs then a drop in compression will help. Above that and you will need to drop it even more. I believe at some point the compression and big boost number will cause the motor to expend excessive amounts of energy to push the piston to TDC on the compression stroke. Reducing this to the optimum number will let it put more of that power out the flywheel. The way a motor makes power is from expanding oxidizing gasses. If you start at a much higher pressure then needed to fascinate this action to its most efficient point of producing maximum peak cylinder pressure at the right time, say 15 to 20 degrees ATDC , then you are wasting power. Anything produced much after that point is totally worthless in making an appreciable power gain. So all the fuel in the world after that point is not going to make power, but will produce a carburized partially oxidized mixture, that did not release its stored energy. Or in other terms SMOKE
Now for the real answer, I would on most 600 hp or below street engines put a thicker head gasket on when you O-ring, and when you get serious and put a cam in the motor, cut the pistons. This will make the best power you could possible use. Some where in the neighborhood of . 025 to . 040 is enough, to clear a good street cam and drop the compression ratio a full point.
Cams, If you aren’t doing cams you way behind the power curve, the best cams out there now are for either John Russin at Buddha power, or Bullet Racing cams. Everything else is just these two groups reverse engineered stuff, and is out of date with the new stuff being worked on so when you want to buy one of these so called new cams that are the be all to end all cams , remember these are two to three year old designs . The newest stuff is light years better. But it is only a mater of time before some of the reverse engineering pros on here will con some one, LIKE ME in to being helpful and selling them a grind and then copying it.
You know who you are, and you know if funny the big be all to end all cam, you copied and now are marketing is one of John Russin 3 to 4 year old design cam I had laying around after progressing to the next 3 or 4 cams John has helped me with. The Cams John is now doing are dramatically better on spool up and power.