I am in this same situation, but I look at it like this-
What do you plan to do with the truck?
I want big power, but have to tow.
What are you willing to spend?
I have seen twins range from 3k to 6K. Thats a lot on coin.
For me, and I have had people pushing twins on me bigtime, I just can't see spending 4-5 grand on turbos when there are so many good singles out there. I agee that twins are the way to go for effiency and turbo life, but the costs are just way up there. Also, depending on the truck and set up, there are other things required with turbos. O-ringing the head or fire rings, head studs, blown head gaskets, and I am sure there are others. I want twins in the worst way but unless they come down in price I will be saving like crazy to move up to a single that is engineered for my application. If you have the wallet, twins are the only way to go. I just don't have the wallet.