I use Marvel Mystery Oil in my 12V occasionally, about once every 3 tanks. It is the only additive I have used that consistently boosts my mpg, but it only kicks it up about 0. 5 mpg. This is based on quite a bit of data, I track my mileage closely and log everything I burn. The tanks with MMO have higher mpg and truck runs pretty good on it.
I have tried several of the other additives, in fact I just finished up testing one of the large jugs of Power Service (white jug, 96 oz ) that I have been running in various tanks since back in the winter. I actually get lower mpg with Power Service than plain diesel, I have noticed similar results with other brands. Besides MMO, Stanadyne seems to work about the best - doesn't boost mpg but it gives more "seat of the pants" than plain diesel and appears to a good job of cleaning.
For 12V folks, probably reasonable every 3-4 tanks to put in the cheapest product that will clean the injectors well. For 24V, lubricity of the fuel is a potential problem so it makes sense to put in a lube additive like Power Service more frequently. Very cold weather would justify putting in some anti-gel. But for every-tank use, none of them seem to be cost effective.
Just reporting my experience, I am not a dealer or stockholder or "emotionally invested" in any of the above products.