Yup - they all sound different for good reasons too...
Injection pressure from early models to late models has increased significantly... . so has the amount of timing - all in an effort to reduce emissions, increase throttle response, increase efficiency.
Out of all the 'pump-injector' 6BT's - the 1st Gen trucks with the VE-44 are the most quiet.
The 2nd Gen P-7100 pumps are in the middle of the road - that P-7100 itself makes a TON of racket.
The 2nd Gen VP-44 equipped engines are the loudest of the bunch - they have the most timing and highest injection pressures out of the 1st/2nd Gen trucks.
The 3rd Gen (common rail injection) ISBe's are the most quiet out of them all - I'm even of the opinion that the '04. 5+ trucks are quieter than the '03-04. 4 trucks... due to the added injection event... and possibly quieter than the GM Duramax.
With multiple injection events (2 or 3), (on the 3rd Gens... ) the cylinder pressure increases in stages - instead of one injection event and one big noisy combustion event.
I've also heard a few 2nd Gen ISB's with EDM injectors that were much more quiet than the 'usual' ISB... again - it has to do with injection pressure and how (efficiently) you're burning a given slug of fuel in the cylinder. Piston shape, compression ratio, and even injector protrusion/placement also play a role in this whole game...
Matt