I have drilled and tapped 2 manifolds with the 1/4NPT threads, with no problems. Both 1st Gens, though I dont think that would make any difference.
AS for pre vs post turbo placement, it depends on what your plans are BOMB wise. If you plan on adding a bigger air filter, and maybe a timing box only, keeping output under 250RWHP, then I'd say post turbo is fine for you. If you plan to go any higher than that, I'd put it pre turbo. On my (then) near-stock 1st Gen, I could hit 1400 going up a hill empty, making only 24psi boost. I had had the t-couple post turbo for a week or so, and never saw 900, at 28psi. How hot I actually was at 28psi, I have no idea, but I'd be willing to be it wasnt safe. 50K later on a PDR HX35 (which had 20K when I bought it used), I have had no problems. I just wait till it is BELOW 300; more like 250-275.
Daniel