It really only makes a difference on how the truck responds under acceleration. Once cruising, the fueling is equal between the levels. So it really comes down to how you want the truck to "feel", and how much smoke you want to make. And the frequency of cleaning the rear quarter panel.
Stacking a timing box such as a Comp on top of a tuner that does timing as well is a bad idea. Either one is advanced about as much as the engine can take, and if you put them together the timing adds up. If you feel the need to throw a Smarty in the mix, you'd need to run one of the non-timing programs. But that would negate one of the great selling points of the Smarty. Mix the Smarty with a non-timing box such as a TST Powermax though and you'd be good to go.
Stacking a timing box such as a Comp on top of a tuner that does timing as well is a bad idea. Either one is advanced about as much as the engine can take, and if you put them together the timing adds up. If you feel the need to throw a Smarty in the mix, you'd need to run one of the non-timing programs. But that would negate one of the great selling points of the Smarty. Mix the Smarty with a non-timing box such as a TST Powermax though and you'd be good to go.