I think you can expect the transmission to grenade, especially if it's a 48re. I've had a basic Juice/ Attitude on my truck for about 23K miles. I've got 30K and I think my 48re is on it's way out?? I don't blame D/C as I added the box, and I like to run on settings 2-3 a lot, and occasionally will run it on #5 here and there. The result is now every time the truck goes into lock/up in 4th I am registering approximately 2-3% slip regularly. I used to only get it to register 2-4% when running on #5 and hard.
-Ryan