The '06 trucks have a hydro-formed frame, but I'm not sure what they're referring to on the electrostatic part.
I do know that I've mounted many things that I've had to drill through the frame for... traction bars, running boards, oil gaurd bypass filter setup, walbro fuel pump, etc.
As long as you're drilling holes 1/2" or smaller, and stay a couple diameters away from the edge, I don't see it being a problem. I'm really confused as to why it would cause an electrical problem.
--Eric