We suggest to all customers that they open the bleeders when they compress the pistons to push all the dirty brake fluid out... and when the new pads are installed they than expect to use at least a quart, sometimes 2 quarts to bleed and flush the brake until the brake fluid comes clear at the caliper...
The industry suggest starting with the longest caliper/wheel cylinder first... even if your doing the front brakes it good policy to bleed all of them...
We go one step farther on our trucks... we pull the bleeders, clean them with a torch tip cleaner as needed and put a dab of anti-seize on the threads as they go back together.
Since we see over 150K miles per vehicle for brakes, which is 2-4 years we will at the 2 year mark bleed and flush only...
We used to use pressure bleeders... and quit using them when we started to see plastic reservoirs, and to be honest other than needed 2 people to do the job mechanically it works well doing it by hand...
On the clutch systems we remove the slave cylinder and have someone compress it by hand... . pushing it all the way back... we suck out the old brake fluid and replace it with fresh... we don't open the system... you don't see the heat and water absorbency as much in the clutch as you seem to in the brakes and I can only assume it has to do with the heat that migrates into the pistons. .