Check your U joints. I developed a terrible noise about 70 mph but couldn't think it could be U joints as I just had the silicone between the transmission and the T case fail and cause me to start throwing transmission oil all under the rig including the wheel wells. When the T case was out I had all the seals replaced. I assumed the service tech would notice a problem with the U joints since he had the T case out - but no such luck. It turns out that one of my bearing end caps on the U joint was busted - the bearings were falling out. I thought I was having a tire separation problem so I took the rig to Les Schwaub and one of the tech's went with me for a ride, and he didn't think it was a tire. We pulled over and he looked underneath and sure enough he saw the problem. Mind you this was 5:15 PM and by the time we got back to the store it was 5:40. We got her apart and fixed within an hour! This is a POS U JOINT from the factory! Check them! My truck has 97,000 and the slip yoke U joint was not bad but broken! Replaced both with HD U joints from Baxter Automotive here in Portland. I can't believe the cheap ones that came standard.
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