Many will recommend using additives to lubricate. I have used several. And use them on about every other tank.
The only lubrication (and cooling) your fuel pump gets and the only lubrication of your injectors comes from the fuel flowing through it. Ultra Low Sulfur Diesel doesn't lubricate very well. Some will argue that the fuel pump and injectors on these new trucks are designed to not need lubrication. But I don't buy that. These fuel systems are under such high pressure, the parts need lubricated and cleaned (IMHO).
As for cleaning, the filters do a good job of removing foreign particles, but it is possible for gum or deposits (slowly developing precipitations coming from the oxidation of fuel or pressurization of fuel) stick to things and could build up. As for cleaning, additives probably don't do a great job of cleaning gums and deposits unless you regularly use these additives. I have used opti lube and stanadyne for lubrication. I like opti lube slightly better. I use power service bio kleen annually to make sure there's no critters lurking in my fuel.
If it was available in my area, I would use a tank of B20 before each filter change even though Ram doesn't recommend switching back and forth between biodiesel and petro diesel. The solvent characteristics of the B20 will/would help clean out any gums or fuel deposits. I would just be careful with that because starving my fuel pump of fuel would overheat it pretty quick. That could happen if the fuel filter clogs from the gums/deposits collecting in the filter.
You will see in the owners manual that Ram recommends using a high cetane fuel if available in your area. The additives clean (a bit), lubricate (alot), and increase the cetane number improving your combustion. I saw a video where a guy said he virtually eliminated soot from his engine by using Amsoil's additive. But I know that was just hype. You probably won't notice reduced soot in your engine, but it could be possible that if your engine runs more efficiently, soot production might reduce slightly. But this last statement is debatable.