Hi Ron
The amount of timing that is "ideal" for an engine depends on a whole host of variables. Among the most important of these are engine load and compression ratio.
You'll note that here on the TDR there are plenty of guys running the EZ or Comp and towing VERY heavy loads (like Rusty, for example

)
But if you are setting out from the get-go to build a truck that can haul the BIG loads, then you want NO additional timing advance. Increased timing advance DRASTICALLY increases peak cylinder pressure and shock loading of pistons, rods, cranks, and especially-- HEAD GASKETS.
Therefore, you don't want to advance timing beyond a VERY narrow range, and it's probably even better left alone for heavy towing.
All the power boxes from Edge advance timing. This means all the "clones", too, like the BD race pro, the Diesel Dynamics Ultimate Fueling Module, etc. While these products will often dyno higher HP than some others, this is not necessarily indicative of their towing performance.
The reason that an HO truck needs a slightly different hot-rod recipe lies in the fact that it is a slightly different engine. It uses smaller injectors than a standard output engine, and a different injection pump which discharges fuel more aggressively. This is why it can make more power EVEN with smaller injectors, and it explains why HO engines gain more HP from injectors alone than an SO engine does.
I'd HIGHLY recommend an adjustable fueling box with NO additional timing advance. Namely, TST's Powermax, and Blue Chip's FMS or APB. The TST is tough to beat for price/performance. Don't mess with the Competition version of the TST box on an HO truck-- it will just give you more smoke and EGT, not much more power-- AND it is harder on the pump.
I'd also recommend some smallish EDM injectors from F1 diesel. The Mach 1. 5s are THE STANDARD in 24V injector efficiency. NO aftermarket injector delivers better MPG. It just happens to give you about 100hp (because you have an HO-- otherwise they are 85hp).
EGTs should also be controllable with the box off and just running the injectors.
If you have to choose between a box and injectors, do the box first, but don't crank it up. A TST powermax 3 should give you enough towing power. Then, once you get the Mach 1. 5s, you can turn the box down and enjoy a happier engine and better mpgs.
Justin