Larger injectors may or may not increase MPG.
Since they injector fuel with a faster rate-of-discharge, that means that they take less time to deliver X amount of fuel. That means that a higher percentage of the fuel is injected near TDC, when the intake charge is hottest. This can mean a more complete or faster burn.
The problem is that a lot of injectors atomize poorly as a result of the process that make them flow more. Usually, this is associated with extrude-honing, as you just don't have much control over where the metal is eroded from using an abrasive slurry.
The number of holes is important too, as it determines overall injector flow for a given size, obviously. But under certain conditions, multiple holes can be harmful to efficiency.
In the early days of Don M's EDM injectors, he experimented with different hole counts, as many as 14 holes (I've heard up to 22 holes). While they were VERY clean on the bottom end and made a LOT of torque, when boost came up, they would smoke like crazy. Why? Because the holes were so small that the fuel couldn't efficiently flow out of them under conditions of intense cylinder pressure.
They began to see "weird" things happen, like 8 hole injectors running cleaner than the 14 hole ones!
As far as I know, ALL Don's EDM injectors are now 8 hole. This design was just cleanest and most efficient overall.
Also, the Mach 1. 5s are the highest mpg injector he makes. It would seem that the mach 1 (smaller holes) might be more efficient, or maybe even the mach 2 (more of the "good" effects of a larger injector). But neither is true-- the 1. 5 is the "sweet spot".
The only proven mpg injectors I know of are the RV275s and the Mach 1. 5s, though I know of good results with a set of mach 1s I installed (22-24mpg empty on an '01. 5 ETH).
Injector efficiency isn't about larger or smaller necessarily- it's about the "right size". Call it the Goldilocks effect.
I personally think injectors between 70 and 90 hp are a good range for overall efficiency if well made. Unfortunately, there are huge difference from one brand injector to another brand, so that's a statement to take with a grain of salt.
In short, you want mpg-- go 275s or Mach 1. 5s. All others may help or hurt mileage.
JMHO