Brett,
I pulled the original injectors out of my truck at 111,000 miles and tested them even though the truck seemed to run great. I have a pop tester and found every one of them started squirting fuel from the tips well before they popped off. A properly functioning and adjusted injector won't leak a drop before it pops off cleanly and releases a jet of fuel. Also, I found they all popped off at a pressure well below the minimum acceptable limit. I disassembled, ultrasonically cleaned, and reassembled them, and while I could raise the pop pressure back to normal, I couldn't get them to stop leaking fuel before they popped off. In short, the original injectors were simply worn out and the tips could no longer seal properly.
The truck seemed to start and run fine, so I'm not sure what functional difference it made. When I installed a set of low mileage original injectors which I'd overhauled, the engine did seemed to idle and run smoother, but I honestly didn't notice too much difference otherwise.
With as many miles as you have on your engine, I have to believe your injectors are leaking before popping off like mine were.
My original VP44 failed at 113,000 miles. It was intermittently throwing a P0216 DTC for almost a year prior to failing completely so I had plenty of warning. I'd already purchased a replacement and was simply waiting for some sign that it was really time to do the swap. That day came when I got the dreaded "dead pedal" while on vacation near Death Valley, CA. I was prepared with all the tools and supplies needed on hand and I swapped it out in the RV park where we were staying. My vacation wasn't ruined but it cost me the better part of a day and some stress. Next time I see a P0216 DTC, I won't wait so long!
Again, with that many miles on your VP44, IMHO you're now a gambling man. I'd either swap it out when convenient or at least carry a spare!
Good luck,
John L.