You might need a new kidney after you make a few passes over the stretch of bumps Oo. between OKC and Muskogee.
Top off the fuel before you hit Arkansas, and back off on the speed - Especially the first 30 miles in AR.
Don't worry about those WHITE KNUCKLES; the color will come back after you get thru the construction & squeeze lanes in Little Rock.
AR rest areas have a second loop, past the regular parking; it circles around a picnic area, and can come in real handy late at night when you pull in and it looks like the parking lot is FULL. A lot of people don't even realize it is there.
Top off the fuel again in West Memphis, AR.
As you approach the I40/I55 split, keep in the left 2 lanes. The road is rough there and a lot of folks don't know where they are going, so take it easy on the curves. Watch out for another speed trap ON the Mississippi River bridge.
Memphis is another challenge ...
After coming across the bridge with all those lanes, it narrows down. You lose a couple of lanes on the right, then the far left lane ends too. That leaves you with 2 eastbound lanes: the right one MUST go south on the 240 loop (you don't want to go that way!), and the left one MUST go north 240/I40 east. You will immediatly hit construction with a 25mph ramp, and that may seem too fast. You have your own lane coming onto 240; stay in it or get run over!
After you come out of the construction zone the road gets wider, and wider, as there are a couple of extra lanes on the left for the left-exit to Millington. Pick any lane except the last 2 on the left and you are ok. After you pass the Millington exit, you have several miles to make your way over to the FAR LEFT lane for the one-lane left-exit for I40 east. You don't want to miss that turn!
Once you are past that you have smooth sailing on out of town.
It is a long trip. The first time or two you will be wanting to just get there as fast as you can. But you will find the trip is a lot better if you just crank up the radio (You DO have XM, right?), set the cruise control on about 65 except in the mountains, and watch the scenery go by. You won't have to worry much about "slow" traffic or speeding tickets; and with diesel fuel over $2/gallon most of the trip, the lower speeds will save you enough to pay for a good meal.
Let me know when you are headed this way. If I'm free, I could meet you at any truck stop in West Memphis then *show* you the way through Memphis.
Then we can talk about the screwy intersections you will hit on the westbound trip! LOL