Yes, it helps a lot - Thanks for all of the input/comparisons. They have always sounded like good inj's, especially when you hear of stories of someone going straight to 4's from the DD2's and thinking the 4's are just as drivable with more smoothness and 75 more HP. (just one example).
I guess the only way to find out is try them yourself and see if they fit your driving style & wants.
Since I'm less of a "racer" type and want the truck to appear as close to stock as possible, and just want a good running, reliable truck that will haul anything thrown at it without having to baby it up the hills (thats the main concern about using big injectors), want a good rig for exploring ghost towns & hidden lakes in the sierras, metal detecting in the boonies (like Death Valley), I think about that "Pump wire" being tapped and putting more stress on the VP. With 4's, it should be loafing but would still have the inherent timing increase of the big injectors, without being overly rattly & lopey.
Might have to try some one of these days, but will definitely hang on to these RV275's & mild edge box because they are a great running combo, just can use a little more punch from the fueling box sometimes.
Now, Bob4x4 is talking m2's & a ttpm box make a good combo. . ahhhh geez! The problem is he's usually right.
But 4's only (with the quick spool of the HX35) might make for a "sweet" running rig that gets decent mileage as well. And have a happy VP44. That's ALWAYS a good thing. .
Then when "the man" looks at it at one of these random inspection points that are starting to pop up, it will look & sound nice & stock with no power boxes glaring at them, and the stock airbox is working fine with the PSM cold air mod with the black hose which appears stock also.
"Geez officer, not sure why it runs so well. . must be that high quality "BioWillie" fuel I put in the tank back there in Texas??"

Actually, so far the current setup has a lot of flexibility. Should keep it that way, but sometimes you just want to see for yourself how well a product works.