cuda6pack,
I wouldnt be too concerned about the "high" mileage factor unless you have over 750K. Seriously. I had 255K on mine when I had to replace the head gasket (which was blown for almost 10K), and still had the cross hatches in the cylinders. You caould eat soup out of the valve covers. Since acquiring mine with 242K, I have put on a PDR HX35-12, guages, done some modest pump tweaking (AFC spring and pin settings). It had been "turned up" by Cummins Rocky Mountain many years ago, and I just got a hair more out of it. At sea level, empty, I can hit 34psi up a hill. No engine problems so far. I'd be more worried about the fuel system then the internals themselves. Go for it as if it had 50K. Power is about fuel and air. THese engines can take a lot. The pistons, bearings, rods, cam and crank, etc, are the same or similar to the ones used in 2nd gen trucks, and they make 700+ hp.
Daniel