Towing a 5th wheel is like towing a giant air-brake. These trucks are designed to tow at about 65 mph efficently. I would suggest you install a set of gauges, boost, EGT, Fuel pressure.
If you are going to switch up to a box I would suggest the Edge-Comp. From personal experience, I own both an Edge-Comp and the Smarty. The Edge will yield right at . 70 mpg better than the Smarty. I have done the trips and the testing with both.
The biggest mpg gain I got was when I installed a set of Bosh 275's and then the Edge. I got 1. 4 mpg from the 275's and 1. 3 from the Edge for an overall gain of 2. 7. Cruising empty I get anywhere from 22. 9 to 23. 8 with the Edge in 1x1. With the Smarty and the Edge turned off, I got 22. 2 mpg. Understand that I am not bad mouthing here. This is just what I have seen.
Loaded up to 23,000 lbs CGVW, Gooseneck Flatbed with empty 5 ft welding bottles and the Edge in 1x1 over 400 miles from Sherwood, Oregon to 30 miles East of Bend, Oregon and back, through Santiam Pass, I averaged 15. 4 mpg.
My signature show my mods. Guages can tell you allot. The EGT is the quickest indicator of fuel usage. If you know what your peak torque rpm is, that will help out for selecting your gears in the uphill runs.
Driving style will play a big part also. I think you can get another 1 mpg on the bottom end loaded up. Your top end unloaded should be able to come up about 1. 5 mpg. Speed is you enemy above 65mph for mileage.
Oh- almost forgot. Tire pressure as already mentioned for the truck should be max, but also make sure the trailer tires are max also.
