The question will be anwered by the truck. If load, wind, hills, or road speed cause the tranmission to "hunt" ie repeatedly shift back and forth from OD to a lower gear use the button in the end of the shifter to select "Tow/Haul" mode.
You would receive better information if you would tell the membership what year and how your truck is equipped. We don't know if you are driving an early 12 valve or a 2012 ISB6. 7 with six speed automatic.