I have many times with and without the 5th wheel, Lance camper or my Big Tex trailer with a car on it. It's clearly marked, "The Loneliest Highway in America". Make sure all your tires are good, no ST made in China tires and properly inflated. Make sure your truck and trailer are up to snuff and you have plenty of coffee and snacks. Also have an ipod loaded with music or several CD's. Middle of June, July or August may get too hot.
Good luck, george