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Will nicotine craving in humans eventually be treatable? Scientists at Weill Cornell Medical College in New York have a nicotine vaccine that works to stop it in mice. Humans may not be far behind. Resource for this article: visit these days our own blog.
Antibody to be used as Nicotine vaccine
According to the Wall Street Journal, the Cornell study in Science Translational Medicine found that one shot of nicotine vaccine with a gene for nicotine antibody should be put into the liver in order to give out a steady stream of the antibody. One shot was enough for a whole mouse’s lifetime, according to the study, and it fought of 80 percent of nicotine from getting to the brain.
Scientists explained that the mice that got the vaccine ended up with lower blood pressure and heart activity when the nicotine really got to the brain.
What is in the nicotine vaccine
Experts believe that similar outcomes for humans can be expected. Researchers have to do more tests before the vaccine can be used on humans though.
"This is a new strategy that may work," wrote senior study author Dr. Ronald Crystal. "We won't know until [we] do the human studies, but it is a very difficult problem and we need new strategies.
There were two other attempts to create nicotine vaccines in the past, and they used ready-made antibodies to get an immune response. It had to be used every few weeks to work though, so it was considered unsuccessful.
"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect," said Crystal.
Next in the vaccine test
If the vaccine is productive on humans, the behavior of nicotine in non-smokers would be stopped and smokers would have an easier time quitting. First, the vaccine has to be tested on rats and then primates. Tests on human smokers will not happen until that point.
"While we have only tested mice to date, we are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches," he said.
A vaccine for cocaine
http://www.youtube.com/watch?v=ocDkyYoNM-4
Sources
C-Health
International Science Time
Wall Street Journal
Antibody to be used as Nicotine vaccine
According to the Wall Street Journal, the Cornell study in Science Translational Medicine found that one shot of nicotine vaccine with a gene for nicotine antibody should be put into the liver in order to give out a steady stream of the antibody. One shot was enough for a whole mouse’s lifetime, according to the study, and it fought of 80 percent of nicotine from getting to the brain.
Scientists explained that the mice that got the vaccine ended up with lower blood pressure and heart activity when the nicotine really got to the brain.
What is in the nicotine vaccine
Experts believe that similar outcomes for humans can be expected. Researchers have to do more tests before the vaccine can be used on humans though.
"This is a new strategy that may work," wrote senior study author Dr. Ronald Crystal. "We won't know until [we] do the human studies, but it is a very difficult problem and we need new strategies.
There were two other attempts to create nicotine vaccines in the past, and they used ready-made antibodies to get an immune response. It had to be used every few weeks to work though, so it was considered unsuccessful.
"As far as we can see, the best way to treat chronic nicotine addiction from smoking is to have these Pacman-like antibodies on patrol, clearing the blood as needed before nicotine can have any biological effect," said Crystal.
Next in the vaccine test
If the vaccine is productive on humans, the behavior of nicotine in non-smokers would be stopped and smokers would have an easier time quitting. First, the vaccine has to be tested on rats and then primates. Tests on human smokers will not happen until that point.
"While we have only tested mice to date, we are very hopeful that this kind of vaccine strategy can finally help the millions of smokers who have tried to stop, exhausting all the methods on the market today, but find their nicotine addiction to be strong enough to overcome these current approaches," he said.
A vaccine for cocaine
http://www.youtube.com/watch?v=ocDkyYoNM-4
Sources
C-Health
International Science Time
Wall Street Journal
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its not as good as the stuff that we had in Vietnam!!!!!!!
