if you want to look at cost/benefit, consider that there is no box released to active production today that does all three -- timing, pressure, duration. You might find some creative marketing babble out there but thats all it is. To be clear on what I mean, as I have said before: when we talk about fueling boxes performing some function(pressure/timing/duration) we mean that they interace with, intercept, change and or control the engine signals who's primary influence is the parameter of interest. Thus we refer to the boxes by what they directly control, not by the side effects that the ECM does.
The interest in stacking has to do with the desire to combine pressure and duration so that neither one is exploited to its extreems. In the case of pressure boxes you have the potential to pop the pressure relief valve (Edge says don't go over 65 RWHP with pressure). In the case of duration boxes you have decreased efficiency and high EGTs. ergo, folks are trying to cool down their duration boxes (including the TST) with pressure boxes.
now then, the TST is by itself wonderful on low to medium settings, as it mitigates the EGT issue by advancing timing. Still, there are guys who have staked the TST with a pressure box and found a benefit.
The VA duration box suffers from very high EGTs, unlike the TST box set to an equivalent power level, due to the fact that it performs no timing. Widening the fuel pulse width without changing the point in time that it begins amount to, guess what: retarded timing. So guys have found that staking the VA with a simple pressure box (EZ, Bullydog, or quadzilla) gives a benefit. And VA themselves have limited the pulse stretch itself so that EGTs don't go any higher than they already do.
but jcary makes a very good point: The TST box can be adjusted to any power level currently available on any other box, and it will do so with equal or better fuel economy improvements and will not raise rail pressure. And you can sweeten the TST up even more by stacking with one of the simple pressure boxes mentioned earlier. My own experiments show that about 50HP with pressure works very well with the VA box. Others have shown that approximately the same amount is beneficial to the TST (i. e. EZ on level 3).