Doc,
In the world of semi's using a Jake Brake all the time, the only noticable wear anywhere in the drivetrain is the thrust washers/plates/rings (take your pick) on the rear main bearing. This "washer" keeps the crank from moving forward or backward. Generally, even though there is wear noted, it's not enough to worry or even think about.
Just my . 2 cents worth.
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97 2500, extcab, 4x4. BFG 285/85/16 AT, "warmed over" pump, JRE Stage III plate, AFC spring kit, BD gov. spring seats only, 370 injectors, K&N, 4" Edwards Exhaust with Dynomax straight through racing muffler & 5"tip, (Cat got "lost"), EGT, boost, oil & transmission temp. gages, Low Stall torque conv. & BD valve body, silencer ring "exiled", Grover Emergency air horn and a multitude of strobe lights and switches (Vol. firefighter)