Lockers
The biggest drawback with using a lockrite or powertrax or similar locker in the rear is that when you go around corners, the inside wheel gets all the torque because the outside wheel is turning faster, and therefore is spinning free. Since the inside is traveling a shorter distance, this has the effect of higher gear ratio on turns. You may not notice much of an effect with an auto trans, though. The locker also tends to power one wheel at a time, so it may seem that the truck sort of wanders as power switches from one wheel to the other, especially under heavy acceleration on low-traction surfaces.