I ran Red Line's Water Wetter with Prestone II anti-freeze/coolant in a GMC Jimmy (full size) 4x4 I had. It worked very well although, I used the product just after it was first released on the market, so blending the heated (almost boiling) distilled water with the Water Wetter CRYSTALS (to properly disolve the crystals) was a pain in the butt. The newer version is much easier to add.
I haven't tried it in my Cummins ISB although, I've thought about it. As Red Line now produces two versions of the Water Wetter (pink and blue), I asked Dave Granquist (Red Line tech. ) for advice regarding proper selection. The blue is intended for large Diesel engines so I naturally figured he would recommend this one although, he stated the pink version was the proper choice for my Cummins ISB.
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'98. 5 2500 QC 4x4, (BLACK) SLT Sport, ISB, LWB, 3. 54 LSD, A/T, Glasstite Vision II canopy, Line-X spray in liner, 285/75R16 BFG A/Ts on 16x8 M/T Challengers, Warn 4X Boards, Mopar fender flares, front and rear NW Custom stainless steel/rubber mud flaps, Mag-Hytec diff. cover and trans. pan, Edelbrock IAS shocks, Mopar tow hooks, Reese Titan V hitch, Jordan Research Ultima 2020 trailer brake controller, VDO Vision gauges, '00 Sport grille, '00 Sport headlights with PIAA Super White 9007/9004 bulbs, 4-2-7+4 Brite-Box, PIAA Dual Sport 900 auxiliary lights, BD exhaust brake and TorqLoc, Prime-Loc fuel filter relocation kit, Bosch 275 hp. injectors, VA CPC, DD Boost Module, Banks Stinger wastegate actuator, BLACK '00 valve cover, Banks Stinger 4" dia. stainless steel exhaust system, BD LV V-10/Cummins hybrid TC and valve body, BD modified transmission front pump and PressureLoc, Air Bulldog induction hood (with NACA ducts), plus many other trick modifications