In a word, yes. To do it safely (and legally) you'll want a dually.
Mind you I have no first hand experience with a "big" slide in on my truck. Just a little popup on my old 2500. But the wife and I are angling for a 10 or maybe even 11 foot camper, which push 3K.
I've done a lot of reading here and irv2.com about what it takes to tote around a big slide in like you describe and 95% of the responses indicate a dually is needed, not only for safety but for enjoyment on the road. Too many stories of white knuckle drives with 2500's and big campers and interstate speeds and passing semi's.
Personally, I think the 2500 can handle a bigger camper, but the problem is, that's under ideal conditions which as we all know, are a myth.
Your 2500 probably can only handle about a 2300 lb camper if you do the math.
We bought a 3500.
Tim