RBellah; After we thoroughly worn out our OEM 48RE @ 198K miles, my transmission rebuild tech reinforced my understanding about using Tow Haul mode when hauling. He showed me how much stronger mechanically the 48RE 3rd gear is, (and the Performance Clutch Pack he installed). If you're on consistent level road (where is that?), OD should be OK.
Another word I got from various diesel tech sources re: modified fueling schedules, e. g. Smarty, Bullydog, Banks, etc. , is that technically speaking the more aggressive 'selections' are likely be the most efficient IF 'acceleration is slow & smoothly controlled'. The reasoning I understand, is that more fuel is admitted sooner, which provides longer (milliseconds) burning/combustion times. My last 5K trip to/fr FL was 2MPG improvement using Banks Lvl 6 vs Lvl 2. HOWEVER, I found myself driving my truck like I stole it, enjoying the power too much. I've since backed it down to Lvl 4 when hauling, mainly because I have NO control of the wildly aggressive cruise control when entering the KY & GA hills, and wished to 'soften' the throttle response a bit. :-laf now you're stuck evaluating this opinion compared to the hundreds you'll be reading, oh well, education ain't never free; it always costs time or money!
P. S. Anyone know of a method to add a "Constant Throttle" option to our 3rd Gen trucks? With long rolling hills, I wouldn't mind dropping 5MPH on the way up, nor would increasing 5MPH on the down side. "Turn Cruise off. " you say? My rig loves running 75MPH, but that's to much for my RV & I struggle to keep proper track of myself--LOL.