I towed about 10,000 lbs yesterday with Smarty Beta 4. 4 on 60 HP timing program + TST 1x0 with 3* auto timing. This is on top of the 100 HP Flux 2 injectors. Only problem I had was traction taking off from a stop :-laf. The 60 HP program definitely comes on strong off-idle with injectors and twins. No smoke or haze at cruise. However, if I mat it at low boost, then yeah there's a bit of smoke. I also averaged 15. 9 mpg. EGT at 75 mph cruise were ~750* (empty ~ 550-575*). EGT on the rolling hills (constant speed changes and low to high boost) topped about 1100*. I usually have to worry more about the speed limit though when EGT do get to this level.
Normally, though, I tow with the Smarty 30 HP timing program and then use the TST to set the duration. It gives the best smoke control, but retains the low end kick and mileage gains of the Smarty. The 30 HP program to me also seems more "drivetrain friendly" while towing in traffic - smoother shifts and take-offs.
The TST by itself with a pressure box is definitely softer coming on and less smoke off idle. EGT either/or looks to be the same, except at cruise where the Smarty is about 50* lower.
With the Stage 2 CP3, I can just look at the MP8 adjustment knob and the rail pressures will start maxing out under any load just off-idle. Realistically, I can only use about 10% of the MP8 box.
The above was with the small BD towing twins though.
A little off-topic, but to compare with your single turbo application, my single turbo towing experiences were all pre-Smarty: only TST + MP8. When I ran the SPS 66 turbo with 90 HP 3-flow injectors and towed, EGT always sat at 1100* +/-, mileage dropped 2 mpg, constant visible smoke trail empty, loaded, uphill, downhill - didn't make a difference - and surge city

. It really sucked to be towing at one gear lower or 80 mph just to get the turbo "on boost" and out of the surge zone. This was with stock size tires too and 3. 73 axles. I can't imagine how much more it would suck with 35" tires and Oregon's speed limits. Not sure what elevation you're at, but I'm at 5,000-7,000 feet so that didn't help me much either with a large, laggy single.
Then I switched to the SPS62. It was a lot better towing in terms of surge and wider powerband, although the haze under load was always present. EGT were about the same as with the 66 turbo - maybe marginally better. Mileage improved about 1 mpg, but no where near when I ran a 62 or stock turbo.