Harm the seals? No. Uncover latent age-related problems? Possibly.
How many miles on the engine? Has it ever run hot enough or been exposed to other conditions that could harden the seals? Has the oil been changed regularly over its life?
Lube that runs low on total base number (TBN) additives can allow acids to form in the oil; acids lead to sludge formation. Over time, sludge can 'seal up' seals (and other things). A good synthetic lube can clear this sludge, and if the seals have hardened, they can start to leak.