I like to think that the 10,000 mile mark is a pretty safe figure. If you tow alot, then you could switch with less miles, as the added load seems to break them in quicker. It is important to allow some time for full break-in, but I also like to get them on the synthetic as quickly as possible. We have had eight new vehicles in the last 16 years and all were run on synthetic, most were swithed at the 5,000 mile mark. I did have one truck that I switched to synthetic on it's frist oil change which was at 800 miles. This was a mistake, and although it did no damage, it did delay the break-in for a long time. WE run the synthetic oil in everything and they all have a different brake-in schedule. The ATV's (four wheelers) get switched after the first two tanks of fuel are run through. Compressors, after 5 hours of opperation. Lawn mowers after two tanks of fuel. And transmissions after the first filter change and band adjustment, which is 24,000 miles.