Here's my $.02
I went from stock "e"s to 33x12. 6X16. 5 BFG mts, on 9. 75" wide rims. I was concerned with the "d" rating. I tow pretty heavy, and the truck tows more then regular driving.
My e's had some wiggle about 70 mph. I always though I needed a rear sway bar. When I went to the larger wider tire, I have had no squirmy since then. Had to turn up the pump to compensate for the larger diameter tires.

I do pull a goosneck, I recommend them all the time. I also do haul 2 pickup trucks on my goosneck at the same time. See my pics in reader rides. I run the tires at max psi when towing, and 35 when empty. I keep good tires on it all them time. I have not noticed increased tire wear going to the mud tread, but then again, I do spin them "occasionally" from the stop lights.
As a side note, I have noticed most all "camper special" trucks in my area run wagon wheels with a 12. 5 wide tire in the rear, and stock width tires up front. You know the trucks, ford made a bunch of 2wd 3/4 tons set up to haul in the 70's. I reason that a wider tire may be more stable then a narrow one.
Hope you have good luck with your decision. I am "not growed up yet" and won't be going back to stock tires for a long time. I like the way the truck looks, and it does what I need it too, when i need it too.
Michael