Good analysis by all. I will add a little.
I have a 25' car/snowmobile hauler (10K GW), bought in 2003. I have pulled from UT to VA. I had blowouts with "D" rated tires. The last blowout (Oh, the trailer was probaby at 10K GW) was June 2007, I went to Goodyear site and found out the ST tires are rated at 65 MPH. Well, that was an eye opener. I searched internet for "E" ST tires and found Carlisle. I put 4 on and pressured up to 80 psi. My first experience with the new tires, with only 50 miles on tread, was looking down at speedometer and seeing 85. I slowed down and realized that with the 80 psi these tires pull the hauler easier. I have not had a blowout. I have put about 3K miles on the tires.
I think there are many variables to consider:
1. UV rays on tires.
2. Speed of towing.
3. Air pressure of tires. Its critical to Keep tires at 100% + maximum tire pressure. Goodyear web site "suggested" to increase tire pressue by 10% IF towing at 65+ MPH.
4. Highway surface of towing.
5. Balance of tires.
6. There are many more - but its late and I'll stop for now.