I had that exact tire for our trip to Alaska. We put on 10,325 miles, and I stopped in the middle to rotate the tires once. I left with 80% tread on the tires, and returned 23 days later with 10% tread. Total weight was always 20k - 22k. The tires handled superbly, and I put them through alot. Part of the trip included over 500 miles of offroad on gravel/dirt/rutted stuff. This was always in 4wd high, running 40 - 60 mph. Even pulling a 34' bumper pull camper, these tires and the Carli suspension glued the truck to the road incredibly.
Toyo's are arguable the absolute best tire you can buy. The only two categories where they fall short, are treadware and price.
--Eric