I haven't yet, but will try that simply because I already have both turbos and the numbers are close.
The HX-40 isn't big enough to be the big turbo in a twin setup if you are running lots of boost and RPM.
My goal is an efficient 50 psi, and with an automatic I always keep her under 3200 rpm.
With these limitations, I'm still in the efficiency band of the HX-40 although who knows exactly what efficiency that is. Holset doesn't let out their complete efficiency maps for some reason.
I'm going to mount the HX-40 on the manifold so the hot gases go through it first then to the smaller turbo. The cooler air coming out of the first turbo will lose volume and the restrictions from the HX-35 should be lessened.
With the HX-40 on the manifold I should be able to keep the stock intake filter location.
I'll be sure to keep everyone posted on how it works out. The trouble is, there is really a LOT of work to mount and plumb in the second turbo. And to be honest, I'm intimidated right now.
For number gunkies, I suggest getting some turbocharger books like "Turbocharging" by Hugh McInnes. It walks you through crunching the numbers, picking the right turbos and even covers how to calculate for twins and intercooling.
-Chris