I've got a street puller cam in my 12V, and my buddy has a helix 2 in his 12V. Both give comparable improvements in spoolup and egt's, and I'd recommend a cam if you're already set on digging into the engine. If not, then I'd do a new turbo to help airflow first.
Both trucks are heavily overfueled and driven hard, so mileage and smoke differences seem negligible.
Chris