IMO change the filter and clean the fine mesh screen on the upstream side of the fuel heater.
AMOCO Oil Company engineering did extensive research in the 1960's on diesel fuel filter plugging, fuel cloud points, fuel gel points, etc. (Note that cloud point is a term and ASTM Test Procedure that was applied to conventional diesel fuels - as the fuel temperature dropped, the fuel would turn cloudy long before it would gel. The cloudy appearance was the barely visible formation of waxy precipitates that would continue to increase as the fuel temperature dropped. These waxy precipitates would then plug the fuel filters. ) The research found that a dirty fuel filter will increase the chances for partial to full fuel filter pluggage on susceptible fuels when the temperature starts to drop.
On some of the first generation CTD's, a very fine mesh screen was installed on the upstream side of the fuel filter heater. If this is dirty it will also promote flow restriction when the temperature drops.
With respect to bio-diesel, many of these formulations are actually esters that behave quite differently than conventional diesel fuel at lower temperatures. You might want to research the formulation and determine what, if any additive could be used to lower the fuel cloud / gel point.
Give me a call on my work phone if you would like to discuss in further detail.