I found this info on aftermarket wheels at Fritzs' web page:
Rims should maintain the same centerline no matter the size. This means that if the offset is 2", it MUST remain 2". In other words, if the backspace = 4" on a 6" rim, you will need 5" on an 8" rim.
While this is the ideal, it isn't always possible. (There is only so much room to the inside of the wheelwell. )
So, you try to get as close as possible. The Rams seem to do well with a backspace in the 4-5" range in terms of fit. While this is close to optimum for an 8" rim, it starts to place more and more stress as the width rises. A 10" rim would most likely be perfectly fine in all respects. However, a 12" (and the tire that would carry) is starting to place the centerline of the wheel beyond the bearings.
It's up to you if you want to go that large, but I wouldn't expect to be able to use the truck to it's limits without doing damage. If you're just driving it around empty on the road, it should be fine, but add a trailer or large load, and you are adding stress the bearings were not designed to handle. They might do just fine, but it is a gamble.
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