JJ,
I'm mostly speaking from the realm of sport bikes on this one but... You never stick synthetic into a gasser until it has at least 5K on it. You need the time for the rigs to set in the bores. If you don't they won't seal up properly and have a constant blow-by. For the Cummins I would wait until you had at least 10K towing and 20K empty. Mine didn't really break in (no towing and TST boxes) until about 30K. At that time the mileage went up ( about 2MPG), ran smoother, and EGT's were down about 200 degrees. And on top of that the engine will run close to 400K on Dinosaur Guts and the truck will be done before then (unless you put HEAVY MILES on it yearly). Not trying to shy you away from synthetic, just wait until the engine is broken in.
Hope this helps.
Tom