LEFT REAR ! TWICE !!
I've had the left rear tire blowout twice over the years and took plumbing, aluminum paneling, wood work, etc. But, it just depends on the trailer layout, the length of time the tread stays attached and how fast your travelling on the road of life... .
I have had a left rear truck tire let go on the freeway while towing and aside from the damage to the truck, the damage to the trailer when the tread hit it I also had to buy new shorts.
I much prefer a trailer tire lets go than a towing vehicle tire. But in my experience, my preference has very little to do with reality.