IMO, there is no real magic combo. Pick a continuous power level, and tune for it.
Well here's my intention; As you can see from my profile I'm half way there. My next venture is of corse compound turbos and F7 injectors. I spoke to Poole and he was mentioning F1 springs for more valve closing pressure, I'm not sure what good that will do since combustion chamber pressure will surely keep them closed tightly, and more RPM I'm not sure about that either... . I know two things I want to use my KSB-1 and I want F7 injectors, since I have a DD cam in it now. I guess I want to tune for what ever power level compound turbos, F7 injectors, DD Cam shaft, and the DD ultimate fuel module (non defuel) on level 5x5 will produce.
I still need to talk to a few more suppliers, I would like to get my head O ringed and ported and polished and of corse new studs.