If it runs good, and the price is right....
..... Go for it. I bought a 92 W250 from a TDR member- drove from Calhan CO to Chicago to get it. Had 224K when I got it. Needed a little help, but nothign major. AMikonis and I have differing opinions of "some oil seepage" but other than that, it was in good shape. Averaged 22+ mpg on the trip home in July. Traded it for the 91 I have now- both had 241. 5K at time of trade. Mom's has 240K; guy who bought a 93 W350 from me has a 90 with 600K+. If it makes any difference, my engine had the cross hatches in the cylinders- after 190K running hard and getting put away wet- pulled a 40' GN flatbed, loaded with tractors all over the place. I was set to buy a 97 3500 5spd with 290K, until I told the lady at the bank how many miles were on it; she thought I was nuts for even looking at it, and refused to approve the loan. Thing is, it was priced at $9K (in 01); NADA was 12. 5K
If the rest of the truck is in good shape, I'd have no problem buying one with up to about 500K without any knowledge of how it was previously run. Over 500K, and it may take some salesmanship to persuade me... ...
Daniel