This question has already been answered here.
A 3500 looks just like a 4500/5500 when parked side to side but the frame of the bigger trucks is slightly thicker metal and they have slightly taller frame rails on the class 4 and 5. The heavier trucks have 19. 5" wheels/tires, larger brakes, much larger and stiffer springs, and a 76 mph speed governor. The class 4/5 also use a larger, heavier differential as well. And last, the tow hooks are welded on the frame of a 4500/5500 but bolted to the frame of a 3500.
All three use the identical engine and transmission. I own a 3500 and am pleased with it. It is a lot more truck than a 3500 dually pickup.
I started out planning to buy a 4500. It only took a couple of test drives in one to change my mind. IMO a 4500/5500 is not acceptable as a daily driver when unloaded. As a heavily loaded work truck they would probably be fine. Too bad air suspension is not offered.