Good grief!
"Inherently bad design, rod to stroke ratio, 360 will outrun it, blah, blah, blah"
The 454 has been around and moving big loads for a long time. from work mules to race engines, it is a very tough motor to beat.
As a tired and/or poorly maintained smog motor, your's is exactly what the government wanted it to be. But the sky, and your wallet, is the limit on what it can do.
My '88 crew cab 4x4 has a TBI 454. At 160k, it still runs pretty good, but "pretty good" isn't enough, and it uses some oil.
Ready to drop in is a new 454 (0. 030 over) with all the goodies for great torque and fuel economy. Built specifically for a big 4x4 or RV. Edelbrock heads, flat top pistons, MUCH better cam, etc. It has @480hp and pushes 700lb/ft torque, will run on pump gas, and uses all required emissions equipment. Fuel economy will also be MUCH better than stock because this engine is efficient; not smothered.
You can do the same to that MH 454. Forget 12:1 if you plan to travel. E85, and 105 octane race gas, is simply too hard to find.
Aftermarket aluminum heads are getting pretty cheap these days and nothing the factory ever produced can compare. Or you could simply find some early 70's heads (forget closed chamber unless you want a high-octane race motor), flat tops, and good RV cam.
Don't put up with a questionable distributor. Don't even dink around with it. Again, the aftermarket has BRAND NEW units ready to drop in for under $75 that are much better built with performance/towing curves. Headers and Flowmasters (if you like nice sound) or at least free flowing mufflers will gain you both power and economy. You cannot beat either an Edelbrock Performer series carb or a well-tuned Q-jet on that motor.
If you have reservations about what to do, visit edelbrock's website and learn about pre-matched Performer packages. They take the guesswork out and match cam, intake, carb, heads, etc. for your specific needs.
For economy, I drive my Cummins, but for "Great truck" and HP, even with the tired old 454, I drive the Chevy.
There is NOTHING wrong with a good, carbureted 454. the question is going to be: What are you willing to do to it and what can you get away with vs. the smog nazis.
I also have a spare 454 on an engine stand that I built for a dually crewcab 4x4 I had. Straightforward, simple, carbed motor with a good cam and pistons and intake, heads, stainless roller rockers, etc. , etc. Some guy stopped one day and started counting out Ben Franklins until I let him leave with the truck, so the motor has no home now. My son keeps working on me to let him put it in his '73 Camaro... But we're doing a nice 355 for that. It's too bad you're so far away, Gary. I'm putting that one up for sale to free up some space and $2k is all it will take to own it.
Thing is, those old Chevy Big and Small blocks are still the best and easiest motors to do whatever you need to. Cheap, too, as far as motors go. Have some fun!
If my old '83 Chevy class C with a 97k on her little ol' 350 sbc can do the trip we just did so reliably, you can do even better with a 454. And no stinkin' mopar 360 will "outdo" a good 454. Sorry fox, but that isn't even realistic.
BTW Gary, I'd be checking for a serious vacuum leak if I were you. Maybe even the distributor's vacuum advance can. That old smog motor you have looks like a spaghetti nightmare with emissions crap; most of it vacuum operated. Those old rubber hoses like to crack and leak, too. Get yourself a good timing light with built-in advance and decent vacuum gauge. Eliminate the easy and obvious first. If the carb has not been previously messed with, LEAVE IT ALONE unless you are an expert! Most "carb problems" are really ignition problems, and ignition includes vacuum for advance. More good carbs and motors have been ruined by neophites with screwdrivers "adjusting" things they do not understand and then pronouncing them "junk" than you can believe.
A vacuum leak will yield POOR power and economy faster than anything else. Every symptom you describe can very well be caused by something that simple. Engine too lean, high temps, no advance, no power, no mpg...