If you want to remove the knob, just grab hold of it and twist. To put it back on, you'll need to remove the shift emblem to get to the nut, then reinstall the emblem. Just turn on the radio, make yourself comfortable in the front seat and take your time. Piece of cake.
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2001, 3500, Cummins, SLT, 5sp, 3. 54LS, camper/tow package, 4x4, 165 watt backup lights, Thomas powered on-board air system, Grovers.