There are lots of benefits to adjust the tire pressure for the load, and not adjusting the tire pressure has one benefit.. no work required.
What you want for towing is proper air pressure, not overinflated tires. There is a huge difference. On a 2500 the highest RAWR is 6500 lbs, which doesn't take 80 psi on any of the tires offered for that RAWR. For the 6000 lb RAWR trucks with 17" wheels they do take 80 psi for 6,000 lbs thou. With the 18's they need 70 or 75 depending on the tire size to hit the 6,500 RAWR and 60-65 for the 6,000 RAWR. Your avatar truck appears to be a CCSB with 18's, which I think has a 6,000 RAWR. So if you have 265/70R18's you only need 65 psi and with 275/70R18's only 60 psi (which I think will set off the low psi light

). Running commercial you likely have to be far more concerned with placard axle weight ratings than most of us do for private use only where we can go more off of tire limits (at least here in Idaho).
Yes it can be a PITA, and the number of miles between loads will dictate if I change my pressure or not.. but you would be hard pressed to ever find me running 80 psi in the rear tires for more than a few miles unloaded. I don't like the lower traction, improper tire wear, and harsh ride.
As you can tell, I'm not fond of too much pressure

My truck is currently sitting at 55/35, and I have enough to add 500lbs of payload/TW without adjusting air pressure. I'd go to 30 psi for the weight, but that's lower than the recommended minimum of 35. I do go lower for slow speed dirt road driving, as low as 25 in the rear depending on the road/speed.
Think how bad your 2500 would ride if you always had max pressure in the airbags.