I have had to replace two electric door locks on our '02 Durango. Door would lock manually, but not electrically.
Getting the door panel off takes investigation and patience. Look for phillips screws near the mirror, behind the door handle and sometimes at the bottom of the inner panel. Sometimes the screws are hidden behind plastic buttons or in the Durango's case, the Infinity speaker logo plastic button.
Once the screws are removed, you usually have to pull straight up on the panel and maybe outward at the bottom.
Then you get to deal with the plastic door seal and dumb-dumb. A razor blade works very well for this.
Finally, you will see the door lock and will have to figure out how it comes out. Usually 3 torx screws at the back of the door latch.
Unhook all of the cables. They have plastic releases that take some figuring out...
This is done while barely having enough room for your fingers and hand to work between the steel structures and window glass, etc.
As you progress, you will wish the worst on the door designer...
Its do-able, but its a pain...
Good luck.